Product ID:THROMBIN FROM HUMAN PLASMA, T8885
MSDS Date:01/01/1999
FSC:6505
NIIN:00N093117
Status Code:A
MSDS Number: CJWJX

Emergency Phone: 314-771-5765

Info Phone: 314-771-5765

Cage: 21076

Telephone: 314-771-5765

Cage: 21076

THROMBIN

CAS: 9002-04-4

RTECS: XO8950000

OSHA PEL N/K

ACGIH TLV: N/K

LD50 LC50 Mixture:SEE TOXICOLOGICAL INFORMATION.
Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE FATAL IF ENTERS
BLOODSTREAM. MAY BE HARMFUL BY INHALATION, INGESTION, OR SKIN
ABSORPTION. MAY CAUSE EYE AND SKIN IRRITATION. MATERIAL MAY BE
IRRITATING TO MUCOUS MEMBRANES AND UPPER RESP IRATORY TRACT.
PROLONGED OR REPEATED EXPOSURE MAY CAUSE ALLERGIC REACTIONS IN
CERTAIN SENSITIVE INDIVIDUALS. HUMAN SOURCE MATERIAL. INVOLVED IN
CLOTTING. TARGET ORGANS: VASCULAR SYSTEM. TO THE BEST OF
MANUFACTURER'S KNOWLEDGE, THE CHEMICAL, PHYSICAL, AND TOXICOLOGICAL
PROPERTIES HAVE NOT BEEN THOROUGHLY INVESTIGATED.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:EYES/SKIN: IMMEDIATELY FLUSH WITH COPIOUS AMOUNTS OF WATER
FOR AT LEAST 15 MINUTES, WHILE REMOVING CONTAMINATED CLOTHING AND
SHOES. ASSURE ADEQUATE FLUSHING OF THE EYES BY SEPARATING THE
EYELIDS WITH FINGERS. INHALATION: REMOVE TO FRESH AIR. IF NOT
BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT,
GIVE OXYGEN. INGESTION: WASH OUT MOUTH WITH WATER PROVIDED PERSON
IS CONSCIOUS. CALL A PHYSICIAN. WASH CONTAMINATED CLOTHING BEFORE
REUSE.

Extinguishing Media:NON-COMBUSTIBLE. USE EXTINGUISHING MEDIA
APPROPRIATE TO SURROUNDING FIRE CONDITIONS.
Fire Fighting Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS AND FULL PROTECTIVE EQUIPMENT .

Spill Release Procedures:WEAR NIOSH APPROVED RESPIRATOR, CHEMICAL
SAFETY GOGGLES, RUBBER BOOTS AND HEAVY RUBBER GLOVES. SPILLED
MATERIAL SHOULD BE CAREFULLY WIPED UP OR MOISTENED WITH WATER AND
REMOVED. VENTILATE AREA AND WAS H SPILL SITE AFTER MATERIAL PICKUP
IS COMPLETE.

Handling and Storage Precautions:AVOID INHALATION. DO NOT GET IN EYES,
ON SKIN, ON CLOTHING. AVOID PROLONGED OR REPEATED EXPOSURE. DO NOT
USE IF SKIN IS CUT OR SCRATCHED. POSSIBLE SENSITIZER. KEEP TIGHTLY
CLOSED. STORE IN A COOL DRY PLACE. POTENTIALLY BIOHAZARDOUS
MATERIAL.

Respiratory Protection:WEAR APPROPRIATE NIOSH APPROVED RESPIRATOR.
Ventilation:USE ONLY IN A CHEMICAL FUME HOOD.
Protective Gloves:CHEMICAL-RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYEWASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA . PROTECTIVE CLOTHING.
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING.
Supplemental Safety and Health

Appearance and Odor:SOLID.

Stability Indicator/Materials to Avoid:YES
Hazardous Decomposition Products:NATURE OF DECOMPOSITION PRODUCTS NOT
KNOWN.

Waste Disposal Methods:DISPOSAL SHOULD BE MADE IN ACCORDANCE WITH
EXISTING DISPOSAL PRACTICES EMPLOYED FOR INFECTIOUS WASTE AT YOUR
INSTITUTION. OBSERVE ALL FEDERAL, STATE AND LOCAL ENVIRONMENTAL
REGULATIONS.

Toxicological Information:RTECS # XO8950000, THROMBIN. TOXICITY DATA:
IPR-RAT LD50: >40 ML/KG; OYYAA2 28, 329, 1984. SCU-RAT LD50: >40
ML/KG; OYYAA2 28, 329, 1984. SKN-MUS LD50: >3 GM/KG; YACHDS 1, 272,
1973. IPR-MUS LD50: >50 ML/KG; OYYAA2 28, 329, 1984. SCU-MUS LD50:
>50 ML/KG; OYYAA2 28, 329, 1984. IVN-MUS LD50: 7771 UG/KG; YACHDS
16, 669, 1988. TARGET ORGAN DATA: BEHAVIORAL (ALTERED SLEEP TIME);
LUNGS, THORAX OR RESPIR ATION (OTHER CHANGES); KIDNEYS, URETER,
BLADDER (OTHER CHANGES). ONLY SELECTED REGISTRY OF TOXIC EFFECTS OF
CHEMICAL SUBSTANCES (RTECS) DATA IS PRESENTED HERE. SEE ACTUAL
ENTRY IN RTECS FOR COMPLETE I NFORMATION.

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:DATA NOT YET AVAILABLE.

Transport Information:CONTACT SIGMA CHEMICAL COMPANY FOR TRANSPORTATION
INFORMATION.

Federal Regulatory Information:REVIEWS, STANDARDS, AND REGULATIONS:
OEL=MAK. NOES 1983: HZD X3641; NIS 3; TNF 339; NOS 7; TNE 7383; TFE
5915. EPA TSCA SECTION 8 (B) CHEMICAL INVENTORY.
State Regulatory Information: